- Barclay-Lindsey family
- James Walter Barclay served in the House, 1859–1866 (8th–10th)
- father-in-law to Dave Lindsey, grandfather to John Lindsey
- David Sudduth Lindsey served in the House, 1893–1897 (23rd–24th)
- son-in-law to James Barclay, father to John Lindsey
- John Lindsey served in the House, 1921–1923 (37th)
- son to Dave Lindsey, grandson to James Barclay
- James Walter Barclay served in the House, 1859–1866 (8th–10th)
- Bee-Tarver family
- Hamilton Prioleau Bee served in the House, 1851–1859 (3rd–7th)
- brother-in-law to Edward Tarver, father of Carlos Bee
- Edward Rex Tarver served in the House, 1895–1897 (24th), 1899–1900 (26th)
- brother-in-law to Hamilton Bee, uncle to Carlos Bee
- Carlos Bee served in the Senate, 1915–1919 (34th–35th)
- son to Hamilton Bee, nephew to Edward Tarver
- Hamilton Prioleau Bee served in the House, 1851–1859 (3rd–7th)
- Benavides family
- Bacilio Benavides served in the House, 1859–1861 (8th)
- uncle to Santos Benavides
- Santos Benavides served in the House, 1879–1885 (16th–18th)
- nephew to Bacilio Benavides
- Bacilio Benavides served in the House, 1859–1861 (8th)
- Blount-Owsley family
- J.M. Blount served in the Senate, 1866–1870 (11th)
- father to James P. Blount
- James P. Blount served in the House, 1885–1887 (19th)
- son to J.M. Blount, brother-in-law to J.G. Kearby
- J.G. Kearby served in the Senate, 1891–1895 (22nd–23rd)
- brother-in-law to James P. Blount
- Alvin Clark Owsley served in the House, 1889–1892 (21st–22nd), and 1895–1897 (24th)
- father to Alvin M. Owsley, son-in-law to J.M. Blount, brother-in-law to James P. Blount
- Alvin M. Owsley served in the House, 1913–1915 (33rd)
- son to Alvin C. Owsley, nephew to James P. Blount, grandson to J.M. Blount
- J.M. Blount served in the Senate, 1866–1870 (11th)
- Bourland-Day-Manion family
- William H. Bourland served in the House, 1846–1849 (1st–2nd), and 1853–1855 (5th)
- brother to James Bourland
- James G. Bourland served in the Senate, 1846–1849 (1st–2nd)
- brother to William H. Bourland, father-in-law to Samuel Day and A.B. Manion
- Samuel Day served in the House, 1873–1874 (13th)
- son-in-law to James Bourland, brother-in-law to Austin Brooks Manion
- Austin Brooks Manion served in the House, 1876–1879 (15th)
- son-in-law to James Bourland, brother-in-law to Samuel Day
- William H. Bourland served in the House, 1846–1849 (1st–2nd), and 1853–1855 (5th)
- Burleson-Loyd-Negley family
- Edward Burleson served in the Senate, 1846–1851 (1st–4th)
- great-uncle to A.J. Loyd, great-grandfather to Laura Burleson Negley
- Andrew Jackson Loyd served in the House, 1899–1901 (26th)
- great-nephew to Edward Burleson
- Laura Burleson Negley served in the House, 1929–1931 (41st)
- great-granddaughter to Edward Burleson
- Edward Burleson served in the Senate, 1846–1851 (1st–4th)
- Camp family
- John Lafayette Camp, Sr. served in the Senate, 1874–1875 (14th)
- father to John L. Camp, Jr., grandfather to W. Nunnelee Camp
- John Lafayette Camp, Jr. served in the Senate, 1885–1889 (19th–20th)
- son to John L. Camp, Sr., uncle to W. Nunnelee Camp
- W. Nunnelee Camp served in the House, 1911–1912 (32nd)
- nephew to John L. Camp, Jr., grandson to John L. Camp, Sr.
- John Lafayette Camp, Sr. served in the Senate, 1874–1875 (14th)
- Canales family
- José Tomás Canales served in the House, 1905–1911 (29th–31st) and 1917–1921 (35th–36th)
- uncle to Terry Canales, great-uncle to Gabi Canales and Terry A. Canales
- Terry A. Canales served in the House, 1973–1977 (63rd–64th)
- father to Gabi Canales and Terry A. Canales, nephew to J.T. Canales
- Gabi Canales served in the House, 2003–2005 (78th)
- daughter of Terry A. Canales, sister of Terry Canales, great-niece to J.T. Canales
- Terry Canales serves in the House, 2013–present (83rd–86th)
- son of Terry A. Canales, brother of Gabi Canales, great-nephew to J.T. Canales
- José Tomás Canales served in the House, 1905–1911 (29th–31st) and 1917–1921 (35th–36th)
- Caven family
- Hubbard Scott Caven served in the House, 1931–1935 (42nd–43rd)
- uncle to Walter Caven
- Walter Thomas Caven served in the House, 1949–1951 (51st)
- nephew to Hubbard Caven
- Hubbard Scott Caven served in the House, 1931–1935 (42nd–43rd)
- Cocke family
- Frederick Bird Smith Cocke, Sr. served in the House, 1861–1863 (9th), and 1879–1881 (16th)
- father to Fred Cocke, Jr. and J.R. Cocke, grandfather to William A. Cocke
- James Rogers Cocke served in the House, 1893–1897 (23rd–24th)
- son to Frederick Cocke, Sr., brother to Fred Cocke, Jr., uncle to William A. Cocke
- Frederick Bird Smith Cocke, Jr. served in the House, 1899–1901 (26th)
- son to Frederick Cocke, Sr., brother to J.R. Cocke, uncle to William A. Cocke
- William Alexander Cocke served in the House, 1907–1909 (30th)
- grandson to Frederick Cocke, Sr., nephew to J.R. Cocke and Fred Cocke, Jr.
- Frederick Bird Smith Cocke, Sr. served in the House, 1861–1863 (9th), and 1879–1881 (16th)
- Crabb family
- Hillary Crabb served in the House, 1853 (4th) and 1855–1857 (6th)
- great-grandfather to Joe Crabb
- Joe Crabb served in the House, 1993–2011 (73rd–81st)
- great-grandson to Hillary Crabb
- Hillary Crabb served in the House, 1853 (4th) and 1855–1857 (6th)
- Crawford family
- William Lyne Crawford served in the House, 1892–1893 (22nd)
- uncle to William Lyne Crawford II
- William Lyne Crawford II served in the House, 1909–1911 (31st)
- nephew to William Lyne Crawford
- William Lyne Crawford served in the House, 1892–1893 (22nd)
- Crockett family^
- John McClannahan Crockett
- great-great-great-uncle to William D. Crockett
- William D. Crockett served in the House, 1905–1911 (29th–31st)
- great-great-great-nephew to John McClannahan Crockett
- John McClannahan Crockett
- Cuellar-Martinez family
- Renato Cuellar served in the House, 1987–1997 (70th–74th)
- uncle to Armando Martinez
- Armando Martinez serves in the House, 2005–present (79th–86th)
- nephew to Renato Cuellar
- Renato Cuellar served in the House, 1987–1997 (70th–74th)
- Daniel family
- Price Daniel, Sr. served in the House, 1939–1945 (46th–48th)
- brother to Bill Daniel, father to Price Daniel, Jr.
- Bill Daniel served in the House, 1949–1955 (51st–53rd)
- brother to Price Daniel, Sr., uncle to Price Daniel, Jr.
- Price Daniel, Jr. served in the House, 1969–1975 (61st–63rd)
- son to Price Daniel, Sr., nephew to Bill Daniel
- Price Daniel, Sr. served in the House, 1939–1945 (46th–48th)
- De La Garza family
- Eligio De La Garza served in the House, 1953–1965 (53rd–58th)
- uncle to Eddie De La Garza
- Eddie De La Garza served in the House, 1991–1997 (72nd–74th)
- nephew to Eligio De La Garza
- Eligio De La Garza served in the House, 1953–1965 (53rd–58th)
- Dies family
- W.W. Dies served in the House, 1897–1901 (25th–26th)
- uncle to Martin Dies, Jr.
- Martin Dies served in the Senate, 1959–1967 (56th–59th)
- nephew to W.W. Dies
- W.W. Dies served in the House, 1897–1901 (25th–26th)
- Dougherty-Leo family
- Edward Dougherty served in the House, 1859–1861 (8th)
- father-in-law to Alexander Leo, Jr.
- Alexander Leo, Jr. served in the House, 1883 (18th)
- son-in-law to Edward Dougherty
- Edward Dougherty served in the House, 1859–1861 (8th)
- Dunnam family
- W.V. Dunnam, Sr. served in the House, 1917–1919 (35th)
- grandfather to Jim Dunnam
- Jim Dunnam served in the House, 1997–2011 (75th–81st)
- grandson to W.V. Dunnam
- W.V. Dunnam, Sr. served in the House, 1917–1919 (35th)
- Durant family
- John Durant served in the Senate, 1861–1866 (9th–10th)
- uncle to William Durant
- William Durant served in the House, 1883–1885 (18th)
- nephew to John Durant
- John Durant served in the Senate, 1861–1866 (9th–10th)
- Farrar-Duff family
- Bowd Farrar served in the House, 1925–1933 (39th–42nd)
- uncle to Virginia Duff
- Virginia Elizabeth Duff served in the House, 1951–1963 (52nd–57th)
- niece to Bowd Farrar
- Bowd Farrar served in the House, 1925–1933 (39th–42nd)
- Faubion family
- James Henry Faubion served in the House, 1885–1891 (19th–21st), 1893–1895 (23rd), and in the Senate, 1903–1905 (28th)
- uncle to H.E. Faubion
- Herbert Elmo Faubion served in the House, 1919–1925 (36th–38th)
- nephew to J.H. Faubion
- James Henry Faubion served in the House, 1885–1891 (19th–21st), 1893–1895 (23rd), and in the Senate, 1903–1905 (28th)
- Few-Lewis family
- William Allen Few served in the House, 1933–1934 (43rd)
- father-in-law to Don A. Lewis
- Donald A. Lewis served in the House, 1947–1951 (50th–51st)
- son-in-law to W.A. Few
- William Allen Few served in the House, 1933–1934 (43rd)
- Fowler family
- John H. Fowler served in the House, 1853–1855 (5th)
- great-uncle to G.R. Fowler
- Godfrey Rees Fowler served in the House, 1903–1905 (28th)
- great-nephew to John H. Fowler
- John H. Fowler served in the House, 1853–1855 (5th)
- Fly family
- George Washington Lafayette Fly served in the House, 1881–1883 (17th)
- father to William Madden Fly, grandfather to William Stoner Fly
- William Madden Fly served in the House, 1915–1923 (34th–37th), and 1926–1929 (39th–40th)
- son to George Washington Lafayette Fly, uncle to William Stoner Fly
- William Stoner Fly served in the House, 1947–1953 (50th–52nd), and in the Senate, 1954–1961 (53rd–56th)
- grandson to George Washington Lafayette Fly, nephew to William Madden Fly
- George Washington Lafayette Fly served in the House, 1881–1883 (17th)
- Garrison-Carter-Sanford family
- Caleb Jackson Garrison served in the House, 1876–1881 (15th–16th), and 1883–1885 (18th), and in the Senate, 1885–1889 (20th)
- brother to T.S. Garrison, uncle to E.H. Carter, great-uncle to Gary B. Sanford
- Thomas Smith Garrison served in the House, 1897–1899 (25th)
- brother to C.J. Garrison, uncle to E.H. Carter, grandfather to Gary B. Sanford
- E.H. Carter served in the Senate, 1911–1914 (32nd–33rd)
- nephew to C.J. and T.S. Garrison, cousin-once-removed to Gary B. Sanford
- Gary Bonner Sanford served in the House, 1922–1927 (37th–39th)
- grandson to T.S. Garrison, great-nephew to C.J. Garrison, cousin-once-removed to E.H. Carter
- Caleb Jackson Garrison served in the House, 1876–1881 (15th–16th), and 1883–1885 (18th), and in the Senate, 1885–1889 (20th)
- Guinn-Hearne family
- Robert Guinn served in the Senate, 1853–1870 (5th–11th)
- brother-in-law to D.T. Hearne
- D.T. Hearne served in the House, 1883–1887 (18th–19th)
- brother-in-law to Robert Guinn
- Robert Guinn served in the Senate, 1853–1870 (5th–11th)
- Hamilton-Perry-Ratliff family
- David Henry Hamilton served in the House, 1893–1895 (23rd)
- great-great-grandfather to Rick Perry
- Rick Perry served in the House, 1985–1991 (69th–71st)
- great-great-grandson to D.H. Hamilton
- Dennis Pace Ratliff served in the House, 1931–1935 (42nd–43rd)
- grandfather-in-law to Rick Perry
- David Henry Hamilton served in the House, 1893–1895 (23rd)
- Hogg family Gov. James Hogg is Joseph's son and Mike's father.
- Joseph Lewis Hogg served in the Senate, 1846 (1st)
- grandfather to Mike Hogg
- Mike Hogg served in the House, 1927–1931 (40th–41st)
- grandson to Joseph L. Hogg
- Joseph Lewis Hogg served in the Senate, 1846 (1st)
- Holland family William is believed to be one of Bird Holland's sons by an enslaved woman. Bird bought the brothers' freedom and took them to Ohio.
- Spearman Holland served in the House, 1846–1847 (1st), 1857–1859 (7th), and 1861–1863 (9th), and in the Senate, 1863–1866 (10th)
- brother to Bird Holland, father to James Holland, uncle^ to William Holland
- Bird Holland served in the House, 1853–1855 (5th)
- brother to Spearman Holland, father^ to William Holland, uncle to James Holland
- William H. Holland served in the House, 1876–1879 (15th)
- son^ to Bird Holland, nephew^ to Spearman Holland, cousin^ to James Holland
- James K. Holland served in the House, 1849–1851 (3rd), and 1863 (9th), and in the Senate, 1853–1855 (5th)
- son to Spearman Holland, nephew to Bird Holland, cousin^ to William Holland
- Spearman Holland served in the House, 1846–1847 (1st), 1857–1859 (7th), and 1861–1863 (9th), and in the Senate, 1863–1866 (10th)
- Jackson-Denny family
- Robert Hal Jackson served in the House, 1947–1951 (50th–51st)
- second cousin to Mary Denny
- Mary Denny served in the House, 1993–2007 (1993–2007)
- second cousin to Robert Hal Jackson
- Robert Hal Jackson served in the House, 1947–1951 (50th–51st)
- Jolley-Bock family
- James Jolley served in the House, 1885–1887 (19th)
- great-grandfather to Bennie Bock II
- Bennie Bock II served in the House, 1973–983 (63rd–67th)
- great-grandson to James Jolley
- James Jolley served in the House, 1885–1887 (19th)
- Jones-Mills family
- Henry Jones served in the House, 1846–1847 (1st)
- father-in-law to Roger Quarles Mills, grandfather to Charles Mills
- Roger Quarles Mills served in the House, 1859–1861 (8th)
- son-in-law to Henry Jones, father to Charles Mills
- Charles H. Mills served in the House, 1913–1915 (33rd)
- son to Roger Quarles Mills, grandson to Henry Jones
- Henry Jones served in the House, 1846–1847 (1st)
- Jones family
- Wiley Jones served in the House, 1863–1866
- father-in-law to John Mathis
- John Manson Mathis served in the House, 1918–1919 (35th), and 1931–1935 (42nd–43rd)
- son-in-law to Wiley Jones
- Wiley Jones served in the House, 1863–1866
- Jones family
- Benjamin Franklin Jones served in the House, 1879–1881 (16th)
- brother to Charles H. Jones and W.H. Jones, father to J.S. Jones
- Charles Hill Jones served in the House, 1866–1870 (11th)
- brother to Benjamin Jones and W.H. Jones, uncle to J.S. Jones
- William H. Jones served in the House, 1876–1879 (15th), and 1885–1887 (19th)
- brother to Benjamin Jones and Charles H. Jones, uncle to J.S. Jones
- James Slaughter Jones served in the House, 1901–1903 (27th)
- son to Benjamin Jones, nephew to Charles H. Jones and W.H. Jones
- Benjamin Franklin Jones served in the House, 1879–1881 (16th)
- Kittrell family
- Pleasant Kittrell served in the House, 1855–1859 (6th–7th)
- grandfather to Norman Kittrell, Jr.
- Norman Goree Kittrell, Jr. served in the House, 1919–1920 (36th)
- grandson to Pleasant Kittrell
- Pleasant Kittrell served in the House, 1855–1859 (6th–7th)
- Lea-Boothe family
- Pryor Lea served in the Senate, 1861–1866 (9th–10th)
- grandfather-in-law to Joseph Boothe
- Joseph Boothe served in the House, 1887–1889 (20th)
- grandson-in-law to Pryor Lea
- Pryor Lea served in the Senate, 1861–1866 (9th–10th)
- Mauritz-Patman family
- Fred Mauritz served in the House, 1935–1939 (44th–45th), and in the Senate, 1941–1947 (47th–50th)
- father-in-law to Bill Patman
- William N. Patman served in the Senate, 1961–1981 (57th–66th)
- son-in-law to Fred Mauritz
- Fred Mauritz served in the House, 1935–1939 (44th–45th), and in the Senate, 1941–1947 (47th–50th)
- Maverick family
- Samuel Augustus Maverick served in the House, 1851–1855, and 1859–1863 (8th–9th), and in the Senate, 1855–1859 (6th–7th)
- great-grandfather to Maury Maverick
- Maury Maverick served in the House, 1951–1957 (52nd–54th)
- great-grandson to Samuel Maverick
- Samuel Augustus Maverick served in the House, 1851–1855, and 1859–1863 (8th–9th), and in the Senate, 1855–1859 (6th–7th)
- McLane-Pierce family
- Charles McLane served in the Senate, 1882–1883 (17th)
- stepfather to C.C. Pierce
- C.C. Pierce served in the House, 1907–1910 (30th–31st)
- stepson to Charles McLane
- Charles McLane served in the Senate, 1882–1883 (17th)
- Meyer-Gattis family
- Charles J.H. Meyer served in the House, 1893–1895 (23rd)
- great-great-grandfather to Dan Gattis
- Dan Gattis served in the House, 2003–2011 (78th–81st)
- great-great-grandson to C.J.H. Meyer
- Charles J.H. Meyer served in the House, 1893–1895 (23rd)
- Mobley family
- John Allen Mobley, Sr. served in the House, 1907–1909 (30th-31st)
- grandfather to John A. Mobley III
- John A. Mobley III served in the House, 1965–1967 (59th)
- grandson to John Allen Mobley, Sr.
- John Allen Mobley, Sr. served in the House, 1907–1909 (30th-31st)
- Moore family
- John Marks Davenport Moore served in the House, 1874–1876 (14th)
- uncle to John Marks Moore
- John Marks Moore served in the House, 1883–1885 (18th)
- nephew to John Marks Davenport Moore
- John Marks Davenport Moore served in the House, 1874–1876 (14th)
- Moursund family
- Albert W.H. Moursund served in the House, 1881–1885 (17th–18th)
- father to Anton N. Moursund, grandfather to Albert Moursund III
- Anton N. Moursund served in the House, 1901–1903 (27th)
- son to A.W. Moursund, Sr., father to Travis Moursund, uncle to Albert Moursund III
- Albert Wadel Moursund III served in the House, 1949–1953 (51st–52nd)
- grandson to A.W. Moursund, Sr., cousin to Travis Moursund
- Travis Bruce Moursund served in the House, 1927–1929 (40th)
- son to Anton N. Moursund, grandson to A.W. Moursund, Sr., cousin to Albert Moursund III
- Albert W.H. Moursund served in the House, 1881–1885 (17th–18th)
- Munson family
- Mordello Stephen Munson served in the House, 1857–1861 (7th–8th), 1866–1870 (11th), and 1875–1876 (14th)
- father to Milam Stephen Munson, Sr., grandfather to Milam Stephen Munson, Jr.
- Milam Stephen Munson, Sr. served in the House, 1909–1911 (31st)
- son to Mordello Stephen Munson, father to Milam Stephen Munson, Jr.
- Milam Stephen Munson, Jr. served in the House, 1931–1935 (42nd–43rd)
- son to Milam Stephen Munson, Jr., grandson to Mordello Stephen Munson
- Mordello Stephen Munson served in the House, 1857–1861 (7th–8th), 1866–1870 (11th), and 1875–1876 (14th)
- Patton-Jordan family
- Edward Patton served in the House, 1891–1893 (22nd)
- great-grandfather to Barbara Jordan
- Barbara Jordan served in the Senate, 1967–1973 (60th–62nd)
- great-granddaughter to Edward Patton
- Edward Patton served in the House, 1891–1893 (22nd)
- Perry-Stevenson-Murr family
- Henry Grady Perry served in the House, 1921–1923 (37th), and 1949–1953 (51st–52nd)
- father to Wilbur Wright Perry, brother-in-law to Coke Robert Stevenson
- Wilbur Wright Perry served in the House, 1953–1955 (53rd)
- son to H. Grady Perry
- Coke Robert Stevenson served in the House, 1929–1939 (41st–45th)
- brother-in-law to H. Grady Perry, grandfather to Andrew Murr
- Andrew Murr serves in the House, 2015–present (84th–86th)
- grandson to Coke Robert Stevenson
- Henry Grady Perry served in the House, 1921–1923 (37th), and 1949–1953 (51st–52nd)
- Rains-Barrett family
- Emory Rains served in the House, 1847–1849 (2nd), 1851–1853 (4th–5th), and in the Senate, 1859–1861 (8th)
- great-uncle to Eli B. Barrett
- Eli Brown Barrett served in the House, 1921–1925 (37th–38th), and 1933–1935 (43rd)
- great-nephew to Emory Rains
- Emory Rains served in the House, 1847–1849 (2nd), 1851–1853 (4th–5th), and in the Senate, 1859–1861 (8th)
- Rowland-Gough family
- James Franklin Rowland served in the House, 1889–1893 (21st–22nd)
- uncle to James Rowland Gough
- James Rowland Gough served in the House, 1891–1897 (22nd–24th), and in the Senate, 1897–1901 (25th–26th)
- nephew to J.F. Rowland
- James Franklin Rowland served in the House, 1889–1893 (21st–22nd)
- Runnels family
- Hiram George Runnels elected but never sworn (7th)
- uncle to Hardin Runnels and Howell Runnels
- Hardin Richard Runnels served in the House, 1847–1855 (2nd–5th)
- brother to Howell Runnels, nephew to Hiram G. Runnels
- Howell Runnels served in the House, 1855–1859 (6th–7th)
- brother to Hardin Runnels, nephew to Hiram G. Runnels
- Hiram George Runnels elected but never sworn (7th)
- Russell family
- William Jarvis Russell served in the House, 1849–1851 (3rd)
- father to William H. Russell, grandfather to W.J. Russell
- William H. Russell served in the Senate, 1874–1876 (14th)
- son to William Jarvis Russell, father to W.J. Russell
- William Jarvis Russell served in the House, 1893–1895 (23rd), and 1899–1905 (26th–28th)
- son to William H. Russell, grandson to William Jarvis Russell
- William Jarvis Russell served in the House, 1849–1851 (3rd)
- Shepard family
- James Shepard served in the House, 1850–1851 (3rd), and 1856–1857 (6th)
- brother to Chauncy Shepard, uncle to Seth Shepard
- Chauncy Shepard served in the Senate, 1857–1866 (7th–10th)
- brother to James Shepard, father to Seth Shepard
- Seth Shepard served in the Senate, 1874–1876 (14th)
- son to Chauncy Shepard, nephew to James Shepard
- James Shepard served in the House, 1850–1851 (3rd), and 1856–1857 (6th)
- Stewart family
- William Henry Stewart served in the House, 1848–1851 (2nd–3rd), and 1859–1861 (8th)
- grandfather to Maco Stewart, Jr., great-grandfather to Maco Stewart III
- Maco Stewart, Jr. served in the House, 1923–1925 (38th)
- father to Maco Stewart III, grandson to William H. Stewart
- Maco Stewart III served in the House, 1961–1963 (57th)
- son to Maco Stewart, Jr., great-grandson to William H. Stewart
- William Henry Stewart served in the House, 1848–1851 (2nd–3rd), and 1859–1861 (8th)
- Stollenwerck family
- John W. Stollenwerck, Sr. served in the House, 1901–1905 (27th–28th)
- grandfather to Henry Stollenwerck
- Henry Stollenwerck served in the House, 1963–1965 (58th)
- grandson to John Stollenwerck
- John W. Stollenwerck, Sr. served in the House, 1901–1905 (27th–28th)
- Tarlton-Morrow-Farenthold family
- Benjamin Tarlton served in the House, 1881–1883 (17th), and 1885–1887 (19th)
- brother-in-law to W.C. Morrow, grandfather to Frances "Sissy" Farenthold
- W.C. Morrow served in the Senate, 1913–1917 (33rd–34th)
- brother-in-law to Benjamin Tarlton, great-uncle to Frances "Sissy" Farenthold
- Frances "Sissy" Farenthold served in the House, 1969–1973 (61st–62nd)
- granddaughter to Benjamin Tarlton, great-niece to W.C. Morrow
- Benjamin Tarlton served in the House, 1881–1883 (17th), and 1885–1887 (19th)
- Terrell family
- Henry Berryman Terrell served in the House, 1901–1909 (27th–30th), and in the Senate, 1909–1915 (31st–34th)
- brother to George Terrell, uncle to J. Turney Terrell
- George Butler Terrell served in the House, 1899–1903 (26th–27th), 1907–1913 (30th–32nd), 1917–1920 (35th–36th), and 1931–1933 (42nd)
- brother to H.B. Terrell, father to J. Turney Terrell
- J. Turney Terrell served in the House, 1930–1933 (41st–42nd)
- son to George Terrell, nephew to H.B. Terrell
- Henry Berryman Terrell served in the House, 1901–1909 (27th–30th), and in the Senate, 1909–1915 (31st–34th)
- Thurmond family
- Pulaski A. Thurmond served in the House, 1863 (9th)
- brother to George Thurmond and Alfred Thurmond
- Alfred Thurmond served in the House, 1866–1870 (11th), and 1873–1874 (13th)
- brother to George Thurmond and Pulaski Thurmond
- George Murat Thurmond served in the House, 1901–1903 (27th)
- brother to Alfred Thurmond and Pulaski Thurmond, father to Roger H. Thurmond, grandfather to George M. Thurmond and Roger H. Thurmond, Jr.
- Roger Harold Thurmond served in the House, 1929 (41st)
- son of George Thurmond, father to George M. Thurmond and Roger H. Thurmond, Jr., nephew to Alfred Thurmond and Pulaski Thurmond
- George Murat Thurmond served in the House, 1955–1959 (54th–55th)
- grandson of George M. Thurmond, great-nephew of Alfred Thurmond and Pulaski Thurmond
- Roger H. Thurmond, Jr. served from 1959–1967 (56th–59th)
- grandson of George M. Thurmond, great-nephew of Alfred Thurmond and Pulaski Thurmond
- Pulaski A. Thurmond served in the House, 1863 (9th)
- Truitt-Stephens family
- James Alfred Truitt served in the Senate, 1846–1849 (1st–2nd), 1851–1853 (4th), 1855–1859 (6th–7th), and 1866–1870 (11th)
- grandfather to James W. Truitt, John H. Truitt, and J.H. Stephens
- Alfred M. Truit served in the Senate, 1849–1851 (3rd)
- son of James Alfred Truitt, uncle^ to James W. Truitt and John H. Truitt
- James W. Truitt served in the House, 1881–1883 (17th), and 1891–1895 (22nd–23rd)
- brother to John H. Truitt, grandson to James Alfred Truitt, nephew^ to Alfred M. Truitt, cousin^ to J.H. Stephens
- John Hays Truitt served in the House, 1887–1889 (20th)
- brother to James W. Truitt, grandson to James Alfred Truitt, nephew^ to Alfred M. Truitt, cousin^ to J.H. Stephens
- John Hall Stephens served in the House, 1889–1893 (21st–22nd)
- grandson to James Alfred Truitt, cousin^ to James W. Truitt and John H. Truitt
- James Alfred Truitt served in the Senate, 1846–1849 (1st–2nd), 1851–1853 (4th), 1855–1859 (6th–7th), and 1866–1870 (11th)
- Wurzbach-Kleberg-Eckhardt family
- Charles Louis Wurzbach served in the House, 1876–1885 (15th–18th), and 1891–1892 (22nd)
- father to William Wurzbach, grandfather to Bob Eckhardt
- William Augustus Wurzbach served in the House, 1895–1897 (24th)
- son to Charles Wurzbach, uncle to Bob Eckhardt
- Marcellus Eugene Kleberg served in the House, 1873–1874 (13th)
- brother to Rudolph Kleberg, uncle to Robert J. Eckhardt, great-uncle to Bob Eckhardt
- Rudolph Kleberg served in the Senate, 1883–1886 (18th–19th)
- brother to Marcellus Kleberg, uncle to Robert J. Eckhardt, great-uncle to Bob Eckhardt
- Robert J. Eckhardt served in the Senate, 1915–1917 (34th)
- uncle to Bob Eckhardt, nephew to Rudolph Kleberg, nephew to Marcellus Kleberg
- Robert C. "Bob" Eckhardt served in the House, 1959–1967 (56th–59th)
- grandson to Charles Wurzbach, nephew to William Wurzbach, nephew to Robert J. Eckhardt, great-nephew to Rudolph Kleberg, great-nephew to Marcellus Kleberg
- Charles Louis Wurzbach served in the House, 1876–1885 (15th–18th), and 1891–1892 (22nd)